| 货号 | 11796-500ug |
| 描述 | Wedelolactone is a natural coumestan originally isolated from plants used in herbal therapies. It inhibits NF-κB signaling at the level of IKK action, resulting in suppression of NF-κB-mediated gene expression at concentrations of 1-100 µM.1,2,3 Wedelolactone can also inhibit hepatitis C virus NS5B RNA-dependent RNA polymerase in vitro(IC50 = 36 µM), STAT1 dephosphorylation (50 µM), and EZH2-EED interactions (Kd = 2.8 µM).4,5,6 Prolonged incubation of HepG2 liver cells with wedelolactone alters lipid metabolism through increased expression of AMPK, PPARα, lipoprotein lipase, and low-density lipoprotein receptor.7 |
| 别名 | IKK Inhibitor II; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kobori, M.,Yang, Z.,Gong, D., et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death and Differentiation 11(1), 123-130 (2004). 2.Yuan, F.,Chen, J.,Sun, P.p., et al. Wedelolactone inhibits LPS-induced pro-inflammation via NF-kappaB pathway in RAW 264.7 cells. Journal of Biomedical Science 20:84, (2013). 3.Alquézar, C.,de la Encarnación, A.,Moreno, F., et al. Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers. J.Psychiatry Neurosci. 41(1), (2016). 4.Kaushik-Basu, N.,Bopda-Waffo, A.,Talele, T.T., et al. Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors. Nucleic Acids Research 35(5), 1482-1496 (2008). 5.Chen, Z.,Sun, X.,Shen, S., et al. Wedelolactone, a naturally occurring coumestan, enhances interferon-γ signaling through inhibiting STAT1 protein dephosphorylation. The Journal of Biological Chemisty 288(20), 14417-14427 (2013). 6.Chen, H.,Gao, S.,Li, J., et al. Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer. Oncotarget 6(15), 13049-13059 (2015). 7.Zhao, Y.,Peng, L.,Yang, L.c., et al. Wedelolactone regulates lipid metabolism and improves hepatic steatosis partly by AMPK activation and up-regulation of expression of PPARa/LPL and LDLR. PLoS One 10(7), (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 314.3 |
| 分子式 | C16H10O7 |
| CAS号 | 524-12-9 |
| 稳定性 | ≥ 2 years |
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