| 货号 | 11724-5mg |
| 描述 | The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine (Item No. 11321), plays a key role in morphogenesis and has potential applications in the treatment of cancer.1,2,3 Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM.4 Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.5,6 |
| 别名 | NSC 17821;NSC 23880; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Heretsch, P.,Tzagkaroulaki, L., and Giannis, A. Cyclopamine and hedgehog signaling: Chemistry, biology, medical perspectives. Angewandte Chemie International Edition 49, 3418-3427 (2010). 2.Xu, F.G.,Ma, Q.Y., and Wang, Z. Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. Cancer Letters 283, 119-124 (2009). 3.Mahindroo, N.,Punchihewa, C., and Fujii, N. Hedgehog-Gli signaling pathway inhibitors as anticancer agents. Journal of Medicinal Chemistry 52(13), 3829-3845 (2009). 4.Tang, J.,Li, H.L.,Shen, Y.H., et al. Antitumor and antiplatelet activity of alkaloids from Veratrum dahuricum. Phytotherapy Research 24, 821-826 (2010). 5.Nagata, R.,Izumi, K.,Iwata, S.i., et al. Mechanisms of veratramine-induced 5-HT syndrome in mice. Japanese Journal of Pharmacology 55, 139-146 (1991). 6.Fukuma, K. Actions of veratramine on the central nervous system. Japanese Journal of Pharmacology 5, 102-114 (1956). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 409.6 |
| 分子式 | C27H39NO2 |
| CAS号 | 60-70-8 |
| 稳定性 | ≥ 2 years |
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