| 货号 | 11505-1mg |
| 描述 | Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis.1,2 ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).3 It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation.4,5 ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).3 It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation.4,5 ABT-888 also acts synergistically with chemotherapies to increase the lethal effects of radiation in cancer cells.6,7 |
| 别名 | Veliparib; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Davar, D.,Beumer, J.H.,Hamieh, L., et al. Role of PARP inhibitors in cancer biology and therapy. Current Medicinal Chemistry 19(23), 3907-3921 (2012). 2.Javle, M. and Curtin, N.J. The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy. Ther. Adv. Med. Oncol. 3(6), 257-267 (2011). 3.Donawho, C.K.,Luo, Y.,Penning, T.D., et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clinical Cancer Research 13(9), 2728-2737 (2007). 4.Albert, J.M.,Cao, C.,Kim, K.W., et al. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clinical Cancer Research 13(10), 3033-3042 (2007). 5.Liu, X.,Luo, X.,Shi, Y., et al. Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage. Cancer Biology and Therapy 7(6), 934-941 (2008). 6.Shelton, J.W.,Waxweiler, T.V.,Landry, J., et al. In vitro and in vivo enhancement of chemoradiation using the oral PARP inhibitor ABT-888 in colorectal cancer cells. Int.J.Radiat.Oncol.Biol.Phys. 86(3), 469-476 (2013). 7.Shunkwiler, L.,Ferris, G. and Kunos, C. Inhibition of poly(ADP-ribose) polymerase enhances radiochemosensitivity in cancers proficient in DNA double-strand break repair. International Journal of Molecular Sciences 14(2), 3773-3785 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 317.2 |
| 分子式 | C13H16N4O • 2HCl |
| CAS号 | 912445-05-7 |
| 稳定性 | ≥ 2 years |
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