| 货号 | 11435-5mg |
| 描述 | Mitomycin C (MMC) is an antitumor antibiotic that was discovered as a fermentation product of S. caespitosus.1 As an alkylating agent, its activity depends on reductive activation either through low pH or DT-diaphorase or NADH cytochrome c reductase.2 Activated MMC crosslinks double stranded DNA and is widely used as a tool to selectively inhibit DNA synthesis and mutagenensis, to stimulate genetic recombination, chromosome breakage and sister chromatid exchange, and to induce DNA repair.3,4 MMC has clinical significance in combination cancer chemotherapy of solid tumors as well as for modulating wound healing after ophthalmological surgeries and in the management of various corneal disorders.5,6 |
| 别名 | Ametycine;MitoExtra;Mitonco;Mitoplus;MMC;NSC 26980; |
| 是否危险品 | 是 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Philips, F.S.,Schwartz, H.S. and Sternberg, S.S. Pharmacology of mitomycin C: I. Toxicity and pathologic effects. Cancer Research 20, 1354-1361 (1960). 2.Mao, Y.,Varoglu, M. and Sherman, D.H. Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. Chemistry & Biology 6(4), 251-263 (1999). 3.Tomasz, M. Mitomycin C: Small, fast and deadly (but very selective). Chemistry & Biology 2, 575-579 (1995). 4.Iyer, V.N. and Szybalski, W. A molecular mechanism of mitomycin action: Linking of complementary DNA strands. Proceedings of the National Academy of Sciences of the United States of America 50, 355-362 (1963). 5.Kato, Y.,Onishi, H. and Machida, Y. Contribution of chitosan and its derivatives to cancer chemotherapy. In Vivo 19, 301-310 (2005). 6.Shao, T.,Li, X. and Ge, J. Target drug delivery system as a new scarring modulation after glaucoma filtration surgery. Diagn.Pathol. 6(64), 1-5 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 334.3 |
| 分子式 | C15H18N4O5 |
| CAS号 | 50-07-7 |
| 稳定性 | ≥ 2 years |
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