Bisindolylmaleimide X (hydrochloride)
货号：
17511-1mg 基本售价：
675.0 元 规格：
1 mg
产品信息
概述| 货号 | 17511-1mg |
| 描述 | Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).1 It has been shown to inhibit PKCα, βI, βII, γ, and ε with IC50 values of 8, 8, 14, 13, and 39 nM, respectively.1 It has also been identified as an inhibitor of Cdk2 (IC50 = 200 nM) and GSK3α/β.2 This compound has been used to activate mesenchymal stem cells, increase the surface expression of homing ligands that bind to intercellular adhesion molecule 1, and target delivery of these cells to sites of inflammation.3 |
| 别名 | BIM X;Ro 31-8425; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wilkinson, S.E.,Parker, P.J. and Nixon, J.S. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochemistry Journal 294, 335-337 (1993).
2.Brehmer, D.,Godl, K.,Zech, B., et al. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol.Cell.Proteomics 3(5), 490-500 (2004).
3.Levy, O.,Mortensen, L.J.,Boquet, G., et al. A small-molecule screen for enhanced homing of systemically infused cells. Cell Rep. 10(8), 1261-1268 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 461 |
| 分子式 | C26H24N4O2 • HCl |
| CAS号 | 145317-11-9 |
| 稳定性 | ≥ 2 years |
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