| 货号 | 16122-1mg |
| 描述 | 7-Ethoxyresorufin (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450 1A1 (Km ranges from 0.11-0.23 µM; IC50 = 0.1 µM).1,2,3 It has been used to study the metabolism of arachidonic acid (Item No. 90010) and the mechanisms of vasodilation.4,5 7-ER also has been shown to inhibit nitric oxide synthesis by uncoupling neuronal nitric oxide synthase (Ki = 0.76 µM).6,7 |
| 别名 | 7-ER;7-Ethoxyphenoxazone;Resorufin ethyl ether; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bourrié, M.,Meunier, V.,Berger, Y., et al. Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes. Journal of Pharmacology and Experimental Therapeutics 277(1), 321-332 (1996). 2.Tassaneeyakul, W.,Birkett, D.J.,Veronese, M.E., et al. Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. Journal of Pharmacology and Experimental Therapeutics 265(1), 401-407 (1993). 3.Dutton, D.R.,Reed, G.A. and Parkinson, A. Redox cycling of resorufin catalyzed by rat liver microsomal NADPH-cytochrome P450 reductase. Archives of Biochemistry and Biophysics 268(2), 605-616 (1989). 4.Labitzke, E.M.,Diani-Moore, S. and Rifkind, A.B. Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase. Archives of Biochemistry and Biophysics 468, 70-81 (2007). 5.Imig, J.D.,Zou, A.P.,de Montellano, P.R.O., et al. Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. American Journal of Physiology.Heart and Circulatory Physiology 35, H1879-H1885 (1994). 6.Li, C.G. and Rand, M.J. Inhibition of NO-medicate responses by 7-ethoxyresorufin, a substrate and competitive inhibitor of cytochrome P450. British Journal of Pharmacology 118(1), 57-62 (1996). 7.Jiang, H.B. and Ichikawa, Y. Neuronal nitric oxide synthase catalyzes the reduction of 7-ethoxyresorufin. Life Sciences 65(12), 1257-1264 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 241.2 |
| 分子式 | C14H11NO3 |
| CAS号 | 5725-91-7 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |