| 货号 | 11741-250ug |
| 描述 | Muristerone A is a natural analog of 20-hydroxyecdysone (Item No. 16145). It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development.1,2,3 Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells.4,5 However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies.6 |
| 别名 | Mur A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zelhof, A.C.,Yao, T.P.,Evans, R.M., et al. Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. Proceedings of the National Academy of Sciences of the United States of America 92(23), 10477-10481 (1995). 2.Landon, T.M.,Sage, B.A.,Seeler, B.J., et al. Characterization and partial purification of the Drosophila Kc cell ecdysteroid receptor. The Journal of Biological Chemisty 263(10), 4693-4697 (1988). 3.Lezzi, M.,Bergman, T.,Henrich, V.C., et al. Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle. European Journal of Biochemistry 269(13), 3237-3245 (2002). 4.No, D.,Yao, T.P. and Evans, R.M. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 93(8), 3346-3351 (1996). 5.Saez, E.,Nelson, M.C.,Eshelman, B., et al. Identification of ligands and coligands for the ecdysone-regulated gene switch. Proceedings of the National Academy of Sciences of the United States of America 97(26), 14512-14517 (2000). 6.Oehme, I.,Bösser, S. and Zörnig, M. Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. Cell Death and Differentiation 13(2), 189-201 (2006). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥96% |
| 计算分子量 | 496.6 |
| 分子式 | C27H44O8 |
| CAS号 | 38778-30-2 |
| 稳定性 | ≥ 2 years |
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