| 货号 | 5168/50 |
| 别名 | 4,5,6,7-Tetrachloro-3',6'-dihydroxy-2 |
| 供应商 | Tocris |
| 生物活性 | Potent VGlut and vesicular monoamine transporter (VMAT) inhibitor (Ki values are 19 and 64 nM, respectively). Inhibits ATP dependent vesicular glutamate uptake (IC50 = 37 nM) and diminishes the amount of exocytotically released glutamate in synaptosomes. Decreases synaptic transmission in the dentate gyrus. Also stains exposed epithelium in the eye. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 1017.64 |
| 分子式 | C20H2Cl4I4 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 50 mM in DMSO |
| 参考文献 | Nealeet al (2013) Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. Neuropsychopharmacology 38 1060. PMID: 23303071. Pietrancostaet al (2010) Rose Bengal analogs and vesicular glutamate transporters (VGLUTs). Bioorg.Med.Chem. 18 6922. PMID: 20708942. Ogitaet al (2001) Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal. J Neurochem. 77 34. PMID: 11279259. Feenstraet al (1992) What is actually stained by rose bengal? Arch.Ophthalmol. 110 984. PMID: 1637285. |