| 货号 | 4107/50 |
| 别名 | 4-(Dipropylsulfamoyl)benzoic acid |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of multidrug resistance-associated proteins (MRP). Inhibits organic acid transport in the kidney and other organs. Also exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 285.36 |
| 分子式 | C13H19NO4S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Ishikawaet al (2010) Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 33 504. PMID: 20190417. Silvermanet al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 295 C761. PMID: 18596212. Hammondet al (2007) Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 282 14337. PMID: 17374608. Cunninghamet al (1981) Clinical pharmacokinetics of probenecid. Clin.Pharmacokinet. 6 135. PMID: 7011657. |