| 货号 | 4098/50 |
| 别名 | 5H-Dibenz[b,f]azepine-5-carboxamide |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of neuronal voltage-gated Na+ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAAreceptorα1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 236.27 |
| 分子式 | C15H12N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 298-46-4 |
| 参考文献 | Lipkind and Fozzard (2010) Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol.Pharmacol. 78 631. PMID: 20643904. Sarkaret al (2009) Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 16 46. PMID: 18636076. Afanas'evet al (1999) Lamotrigine and carbamazepine affect differently the release of D-[3H] aspartate from mouse cerebral cortex slices: involvement of NO. Neurochem.Res. 24 1153. PMID: 10485587. Grangeret al (1995) Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin. Mol.Pharmacol. 47 1189. PMID: 7603459. |