Deltarasin (hydrochloride)
货号：
9001536-1mg 基本售价：
672.0 元 规格：
1 mg
产品信息
概述| 货号 | 9001536-1mg |
| 描述 | KRAS is an oncogene product that acts as a GTPase tethered to cell membranes to assist in various cell signaling pathways. The prenyl-binding protein PDEδ regulates the correct localization and signaling of farnesylated KRAS by facilitating its diffusion to the cytoplasm. Deltarasin is a small molecule that binds to the farnesyl-binding pocket of PDEδ (Kd = 41 nM) in cells thus inhibiting its interaction with KRAS and disrupting RAS signaling.1 Treatment of human pancreatic ductal adenocarcinoma cell models with 5 μM deltarasin has been reported to prevent KRAS plasma membrane localization and subsequent solubilization by PDEδ, resulting in reduced proliferation and increased cell death of Panc-Tu-I tumor cells.1 Furthermore, in nude mice bearing pancreatic carcinoma xenografts, deltarasin has been shown to reduce tumor growth at a dose of 10 mg/kg.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zimmermann, G.,Papke, B.,Ismail, S., et al. Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 497(7451), 638-642 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 691.3 |
| 分子式 | C40H37N5O • 2.4HCl |
| CAS号 | 1440898-82-7 |
| 稳定性 | ≥ 2 years |
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