22(R)-hydroxy Cholesterol
货号：
89355-1mg 基本售价：
672.0 元 规格：
1 mg
产品信息
概述| 货号 | 89355-1mg |
| 描述 | The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols.1 LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. 22(R)-hydroxy Cholesterol is an endogenous agonist for LXRs that activates LXRα with an EC50 value of 325 nM.2 22(R)-hydroxy Cholesterol, acting through LXR heterodimerized with the retinoid X receptor, induces the expression of the ABCA1 reverse cholesterol transporter.3 This activity increases the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol. 22(R)-hydroxy Cholesterol can be used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists which have potential as therapeutic agents for the treatment of atherosclerosis. |
| 别名 | Narthesterol; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Repa, J.J.,Turley, S.D.,Lobaccaro, J.M.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289, 1524-1529 (2000).
2.Spencer, T.A.,Dansu, L.,Russel, J.S., et al. Pharmacophore analysis of the nuclear oxysterol receptor LXRα. Journal of Medicinal Chemistry 44, 886-897 (2001).
3.Costet, P.,Luo, Y.,Wang, N., et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. The Journal of Biological Chemisty 275, 28240-28245 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 402.7 |
| 分子式 | C27H46O2 |
| CAS号 | 17954-98-2 |
| 稳定性 | ≥ 1 year |
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