BC-11-38
货号：
20167-5mg 基本售价：
672.0 元 规格：
5 mg
产品信息
概述| 货号 | 20167-5mg |
| 描述 | BC-11-38 is a potent and selective phosphodiesterase (PDE) 11 inhibitor (IC50s = 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively).1 Gene association studies suggested that PDE11 was involved in adrenal function, and in H295R human adrenocortical cells, BC-11-38 increased cAMP and cortisol levels and activating transcription factor 1 (ATF-1) phosphorylation.2,3,1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ceyhan, O.,Birsoy, K. and Hoffman, C.S. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem. Biol. 19(1), 155-163 (2012).
2.Horvath, A.,Giatzakis, C.,Robinson-White, A., et al. Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population. Cancer Res. 66(24), 11571-11575 (2006).
3.Libé, R.,Horvath, A.,Cezzosi, D., et al. Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype. J. Clin. Endocrinol. Metab. 96(1), E208-E214 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 304.4 |
| 分子式 | C15H16N2OS2 |
| CAS号 | 686770-80-9 |
| 稳定性 | ≥ 2 years |
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