Ki8751
货号：
18004-5mg 基本售价：
672.0 元 规格：
5 mg
产品信息
概述| 货号 | 18004-5mg |
| 描述 | Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. Ki8751 is a potent, orally available inhibitor of the kinase activity of VEGFR2 (IC50 = 0.9 nM).1 It less potently inhibits c-Kit, PDGRFα, and FGFR2 (IC50s = 40-170 nM) and has no significant effect against several other receptor tyrosine kinases. Ki8751 suppresses the growth of VEGF-stimulated human umbilical vein endothelial cells at nanomolar concentrations.1 It shows significant anti-tumor activity against assorted human tumor xenografts in nude mice.1 Ki8751 also induces cellular senescence in colorectal cancer cells.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kubo, K.,Shimizu, T.,Ohyama, S., et al. Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: Synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N-{4-(4-quinolyloxy)phenyl}ureas. Journal of Medicinal Chemistry 48(5), 1359-1366 (2005).
2.Hasan, M.R.,Ho, S.H.Y.,Owen, D.A., et al. Inhibition of VEGF induces cellular senescence in colorectal cancer cells. International Journal of Cancer 129(9), 2115-2123 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 469.4 |
| 分子式 | C24H18F3N3O4 |
| CAS号 | 228559-41-9 |
| 稳定性 | ≥ 2 years |
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