Dexrazoxane
货号：
14632-5mg 基本售价：
672.0 元 规格：
5 mg
产品信息
概述| 货号 | 14632-5mg |
| 描述 | Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα.1 Through these activities, dexazoxane is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury.2 Dexrazoxane has also been shown to act as an antioxidant that scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), 2,2-diphenyl-1-picrylhydrazyl (IC50 = 3.5 μM), and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (IC50 = 3.8 mM) free radicals.3 |
| 别名 | ICRF 187;NSC 169780;Totect®;Zinecard; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yan, T.,Deng, S.,Metzger, A., et al. Topoisomerase IIα-dependent and -independent apoptotic effects of dexrazoxane and doxorubicin. Molecular Cancer Therapeutics 8(5), 1075-1085 (2009).
2.Kurz, T.,Grant, D.,Andersson, R.G.G., et al. Effects of MnDPDP and ICRF-187 on doxorubicin-induced cardiotoxicity and anticancer activity. Transl.Oncol. 5(4), 252-259 (2012).
3.Junjing, Z.,Yan, Z. and Baolu, Z. Scavenging effects of dexrazoxane on free radicals. Journal of Clinical Biochemistry and Nutrition 47(3), 238-245 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 268.3 |
| 分子式 | C11H16N4O4 |
| CAS号 | 24584-09-6 |
| 稳定性 | ≥ 2 years |
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