| 货号 | 13601-5mg |
| 描述 | The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin.1 ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A (IC50 = 250 and 1,000 nM, respectively).2 It has no effect on several other kinases, including Cdk1, Cdk2, Cdk4, Plk1, CHK1, KDR2, and FAK (IC50 > 10 µM).3 ZM 447439 has been used to study the role of Aurora B in molecular events associated with mitosis and cytokinesis.3,4 Moreover, ZM 447439 selectively inhibits proliferating cells rather than non-dividing cells, suggesting its potential in cancer therapy.2 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Carmena, M.,Ruchaud, S. and Earnshaw, W.C. Making the Auroras glow: Regulation of Aurora A and B kinase function by interacting proteins. Current Opinion in Cell Biology 21(6), 796-805 (2009). 2.Girdler, F.,Gascoigne, K.E.,Eyers, P.A., et al. Validating Aurora B as an anti-cancer drug target. Journal of Cell Science 119, 3664-3675 (2006). 3.Ditchfield, C.,Johnson, V.L.,Tighe, A., et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. Journal of Cell Biology 161(2), 267-280 (2003). 4.Gadea, B.B. and Ruderman, J.V. Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts. Molecular Biology of the Cell 16, 1305-1318 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 513.6 |
| 分子式 | C29H31N5O4 |
| CAS号 | 331771-20-1 |
| 稳定性 | ≥ 2 years |
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