| 货号 | 12415-100ug |
| 描述 | Prostaglandin D2(PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1receptor.1 However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2.2,3 This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2.4 11-deoxy-11-methylene-15-keto PGD2 was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2. |
| 别名 | 11-deoxy-11-methylene-15-keto PGD2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Boie, Y.,Sawyer, N.,Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. The Journal of Biological Chemisty 270, 18910-18916 (1995). 2.Gervais, F.G.,Cruz, R.,Chateauneuf, A., et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. Journal of Allergy and Clinical Immunology 108(6), 982-988 (2002). 3.Monneret, G.,Gravel, S.,Diamond, M., et al. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 98(6), 1942-1948 (2001). 4.Hirai, H.,Tanaka, K.,Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. Journal of Experimental Medicine 193(2), 255-261 (2001). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348.5 |
| 分子式 | C21H32O4 |
| CAS号 | 958759-75-6 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |