CAY10583
货号：
10012424-5mg 基本售价：
672.0 元 规格：
5 mg
产品信息
概述| 货号 | 10012424-5mg |
| 描述 | Leukotriene B4(LTB4) promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, superoxide anion production, chemotaxis, and chemokinesis. Two G protein-coupled receptors, BLT1 and BLT2 mediate the actions of LTB4. CAY10583 is a potent, selective full agonist for BLT2 with an EC50 value of 20 nM.1 It does not displace [3H]-leukotriene B4(LTB4) binding to BLT1 at concentrations >1 µM and activates BLT2 at significantly lower concentrations than LTB4(EC50 = 170 nM).1 CAY10583 dose dependently increases intracellular calcium stores and induces ERK phosphorylation in Chinese hamster ovary (CHO) cells expressing BLT2 with no effect on CHO cells expressing BLT1.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Iizuka, Y.,Yokomizo, T.,Terawaki, K., et al. Characterization of a mouse second leukotriene B4 receptor, mBLT2. BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. The Journal of Biological Chemisty 280(26), 24816-24823 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 387.5 |
| 分子式 | C25H25NO3 |
| CAS号 | 862891-27-8 |
| 稳定性 | ≥ 2 years |
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