| 货号 | 14450-1mg |
| 描述 | The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.1,2 DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM.3 It is approximately 10-fold less potent against PARP2.4 DPQ can be used in either cells or in animals.5,6 |
| 别名 | PARP Inhibitor III; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Davar, D.,Beumer, J.H.,Hamieh, L., et al. Role of PARP inhibitors in cancer biology and therapy. Current Medicinal Chemistry 19(23), 3907-3921 (2012). 2.Mathews, M.T. and Berk, B.C. PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. Arteriosclerosis, Thrombosis, and Vascular Biology 28, 711-717 (2008). 3.Costantino, G.,Macchiarulo, A.,Camaioni, E., et al. Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationships analysis. Journal of Medicinal Chemistry 44, 3786-3794 (2001). 4.Eltze, T.,Boer, R.,Wagner, T., et al. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): A comparison with standard PARP inhibitors. Molecular Pharmacology 74(6), 1587-1598 (2008). 5.Fonfria, E.,Marshall, I.C.B.,Benham, C.D., et al. TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. British Journal of Pharmacology 143, 186-192 (2004). 6.Giovannelli, L.,Cozzi, A.,Guarnieri, I., et al. Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: Differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors. Journal of Cerebral Blood Flow and Metabolism 22(6), 697-704 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 302.4 |
| 分子式 | C18H26N2O2 |
| CAS号 | 129075-73-6 |
| 稳定性 | ≥ 2 years |
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