GYY 4137
货号：
13345-10mg 基本售价：
658.0 元 规格：
10 mg
产品信息
概述| 货号 | 13345-10mg |
| 描述 | Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor.1 When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models.1 Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2generation.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Li, L.,Whiteman, M.,Guan, Y.Y., et al. Characterization of a novel, water-soluble hydrogen sulfide releasing molecule (GYY4137): New insights into the biology of hydrogen sulfide. Circulation 117, 2351-2360 (2008).
2.Li, L.,Salto-Tellez, M.,Tan, C.H., et al. GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Free Radical Biology & Medicine 47, 103-113 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 377.5 |
| 分子式 | C11H16NO2PS2 • C4H10NO |
| CAS号 | 106740-09-4 |
| 稳定性 | ≥ 2 years |
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