| 货号 | 11019-5mg |
| 描述 | The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin. TRPV1 is present in primary sensory neurons and in both central and peripheral sensory nerve terminals and plays a role in thermal and mechanical hyperalgesia. SB-366791 is a selective TRPV1 antagonist that is widely used in pain research.1 In cultured trigeminal ganglion neurons, SB-366791 inhibits capsaicin-evoked Ca2+ influx with an IC50 value of 0.7 μM.1 A 1 nmol injection of SB-366791 in mouse paw reduces capsaicin-induced nociceptive responses in a model of pain.2 Intrathecal pretreatment of 10 μl SB-366791 in rats suppresses tolerance to the analgesic effects of chronic morphine administration.3 Co-administration of morphine and SB-366791 at 0.1 mg/kg has potent analgesic effects in a mouse model of bone cancer pain.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Varga, A.,Németh, J.,Szabó, A., et al. Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat. Neuroscience Letters 385, 137-142 (2005). 2.Andrade, E.L.,Luiz, A.P.,Ferreira, J., et al. Pronociceptive response elicited by TRPA1 receptor activation in mice. Neuroscience 152(2), 511-520 (2008). 3.Chen, Y.,Geis, C. and Sommer, C. Activation of TRPV1 contributes to morphine tolerance: Involvement of the mitogen-activated protein kinase signaling pathway. Journal of Neuroscience 28(22), 5836-5845 (2008). 4.Niiyama, Y.,Kawamata, T.,Yamamoto, J., et al. SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain. British Journal of Anaesthesia 102(2), 251-258 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 287.7 |
| 分子式 | C16H14ClNO2 |
| CAS号 | 472981-92-3 |
| 稳定性 | ≥ 2 years |
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