| 货号 | 81590-100ug |
| 描述 | Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM.1 It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively.2 However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms.3 The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.3,4 |
| 别名 | Stsp; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tamaoki, T.,Nomoto, H.,Takahashi, I., et al. Staurosporine, a potent inhibitor of phospholipid/Ca++ dependent protein kinase. Biochemical and Biophysical Research Communications 135, 397-402 (1986). 2.McGlynn, E.,Liβz, J.,Reutener, S., et al. Expression and partial characterization of rat protein kinase C-δ and protein kinase C-ζ in insect cells using recombinant baculovirus. Journal of Cellular Biochemistry 49, 239-250 (1992). 3.Ruegg, U.T. and Burgess, G.M. Staurosporine, K-252 and UCN-01: Potent but nonspecific inhibitors of protein kinases. Trends in Pharamacological Sciences 10, 218-220 (1989). 4.Li, H. and Förstermann, U. Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase gene. Molecular Pharmacology 57, 427-435 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 466.5 |
| 分子式 | C28H26N4O3 |
| CAS号 | 62996-74-1 |
| 稳定性 | ≥ 1 year |
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