| 货号 | 16300-10ug |
| 描述 | Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation.1 Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes.2iPF2α-VI is one of dozens of possible stereo- and regioisomeric isoprostanes which can be formed from arachidonic acid. To date, the most extensively studied of these is 8-isoprostane (8-epi-PGF2α, iPF2α-III).3,4 However, 8-isoprostane is a minor isoprostane constituent when compared to some of the other isomers which form in natural conditions of oxidative stress.5iPF2α-VI is an isoprostane from the unique Type VI class of isoprostanes. This class has been shown to be one of the major isoprostane products, in contrast to 8-isoprostane. In addition to being produced in greater abundance than 8-isoprostane, Type VI isoprostanes form internal lactones, which facilitates their extraction and purification from biological samples.5,6,7,8 |
| 别名 | iPF2α-I; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Morrow, J.D.,Hill, K.E.,Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proceedings of the National Academy of Sciences of the United States of America 87, 9383-9387 (1990). 2.Parchmann, S. and Mueller, M.J. Evidence for the formation of dinor isoprostanes E1 from α-linolenic acid in plants. The Journal of Biological Chemisty 273, 32650-32655 (1998). 3.Delanty, N.,Reilly, M.,Pratico, D., et al. 8-Epi PGF2α: Specific analysis of an isoeicosanoid as an index of oxidant stress in vivo. British Journal of Clinical Pharmacology 42, 15-19 (1996). 4.Reilly, M.P.,Barry, P.,Lawson, J.A., et al. Urinary 8-epi PGF2α: An index of oxidant stress in vivo. Fibrinolysis & Proteolysis 11, 81-84 (1997). 5.Reilly, M.P.,Pratico, D.,Delanty, N., et al. Increased formation of distinct F2 isoprostanes in hypercholesterolemia. Circulation 98, 2822-2828 (1998). 6.Li, H.,Lawson, J.A.,Reilly, M., et al. Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F2-isoprostanes in human urine. Proceedings of the National Academy of Sciences of the United States of America 96(23), 13381-13386 (1999). 7.Lawson, J.A.,Li, H.,Rokach, J., et al. Identification of two major F2 isoprostanes, 8,12-iso- and 5-epi-8,12-iso-isoprostane F2α-VI, in human urine. The Journal of Biological Chemisty 273, 29295-29301 (1998). 8.Praticò, D.,Barry, O.P.,Lawson, J.A., et al. IPF2α-I: An index of lipid peroxidation in humans. Proceedings of the National Academy of Sciences of the United States of America 95, 3449-3454 (1998). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 354.5 |
| 分子式 | C20H34O5 |
| CAS号 | 180469-63-0 |
| 稳定性 | ≥ 1 year |
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