Apicidin
货号：
10575-1mg 基本售价：
644.0 元 规格：
1 mg
产品信息
概述| 货号 | 10575-1mg |
| 描述 | Histone acetyltransferase and histone deacetylase (HDAC) activity regulates the reversible acetylation of lysine residues within histone tails, which results in either transcriptional activation or repression of nearby genes. Compounds that modulate this activity are of interest in cancer chemotherapeutics as well as for treating psychiatric disorders, malaria, and other diseases. Apicidin is a fungal toxin that has broad spectrum activity against Apicomplexan parasites through inhibiting HDACs (IC50 = 0.7 nM).1Anin vitro activity assay demonstrates apicidin inhibition of HDAC3/NcoR, a class I HDAC, at a much higher potency than for class II HDAC6 (IC50s = 15.8 and 665.1 nM, respectively).2 Apicidin exhibits antiproliferative activity against various cancer cell lines (IC50s = 0.13-2.36 μM), and at 0.5 – 2 μM it induces selective changes in p21WAF1/Cip1 and gelsolin gene expression, which control cell cycle and cell morphology, respectively.3 |
| 别名 | OSI 2040; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Darkin-Rattray, S.J.,Gurnett, A.M.,Myers, R.W., et al. Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase. Proceedings of the National Academy of Sciences of the United States of America 93(23), 13143-13147 (1996).
2.Mazitschek, R.,Patel, V.,Wirth, D.F., et al. Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. Bioorganic & Medicinal Chemistry Letters 18, 2809-2812 (2008).
3.Han, J.W.,Ahn, S.H.,Park, S.H., et al. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Research 60, 6068-6074 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 623.8 |
| 分子式 | C34H49N5O6 |
| CAS号 | 183506-66-3 |
| 稳定性 | ≥ 2 years |
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