| 货号 | 14776S |
| 供应商 | CST |
| 背景 | Dexamethasone is a synthetic glucocorticoid that binds to the human glucocorticoid receptor (GR). Treatment of cells with dexamethasone leads to nuclear translocation and activation of GR. This elicits anti-inflammatory, cellular proliferation, and metabolic responses via GR-mediated transcriptional activation or repression of target genes (1-4). Research studies show that dexamethasone inhibits dendritic cell differentiation and maturation (5). The inhibition of nitric oxide synthase by dexamethasone has also been observed (6). |
| 存放说明 | -20C |
| 参考文献 | 1 . Matthews, L. et al. (2009) Endocrinology 150, 75-86. 2 . Cole, T.J. (2006) Biotechnol Annu Rev 12, 269-300. 3 . Beck, I.M. et al. (2009) Endocr Rev 30, 830-82. 4 . Matasić, R. et al. (1999) J Leukoc Biol 66, 909-14. 5 . Moncada, S. and Palmer, R.M. (1991) Trends Pharmacol Sci 12, 130-1. 6 . Wang, Z. et al. (2002) J. Biol. Chem. 277, 26573-26580. |
Western blot analysis of extracts from A549 cells, untreated (-) or treated with Dexamethasone (24 hr) at the indicated concentrations, using β-Arrestin 1 (D8O3J) Rabbit mAb #12697 (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). | |
Western blot analysis of extracts from HeLa cells, serum-starved overnight and untreated (-) or treated with Dexamethasone (1 hr) at the indicated concentrations, using Phospho-Glucocorticoid Receptor (Ser211) Antibody #4161 (upper) and Glucocorticoid Receptor (D6H2L) XP® Rabbit mAb #12041 (lower). | |
Chemical structure of Dexamethasone. |
