Thiostrepton
货号：
19200-500mg 基本售价：
630.0 元 规格：
500 mg
产品信息
概述| 货号 | 19200-500mg |
| 描述 | The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself.1,2 Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells.1 These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.3 |
| 别名 | Bryamycin;NSC 81722;NSC 170365;Thiactin;Thiostreptin A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bhat, U.G.,Halasi, M. and Gartel, A.L. Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells. PLoS One 4(5), e5592 (2009).
2.Gartel, A.L. Thiazole antibiotics siomycin A and thiostrepton inhibit the transcriptional activity of FOXM1. Front.Oncol. 3, 150 (2013).
3.Gartel, A.L. Suppression of the oncogenic transcription factor FOXM1 by proteasome inhibitors. Scientifica (Cairo) 2014:596528, (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1664.9 |
| 分子式 | C72H85N19O18S5 |
| CAS号 | 1393-48-2 |
| 稳定性 | ≥ 2 years |
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