Lanicemine
货号：
9002129-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 9002129-5mg |
| 描述 | Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 µM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 µM.1 Compared to ketamine (Item No. 11630), lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate.1 It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity.1,2 |
| 别名 | AZD 6765;AR-R 15896AR; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sanacora, G.,Smith, M.A.,Pathak, S., et al. Lanicemine: A low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Molecular Psychiatry 19(9), 978-985 (2014).
2.Zarate, C.A., Jr.,Mathews, D.,Ibrahim, L., et al. A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression. Biological Psychiatry 74(4), 257-264 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 198.3 |
| 分子式 | C13H14N2 |
| CAS号 | 153322-05-5 |
| 稳定性 | ≥ 1 year |
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