| 货号 | 21821-500ug |
| 描述 | Ribavirin 5-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis.1,2,3 This agent, a metabolite of the prodrug ribavirin (Item No. 16757), exhibits broad-spectrum antiviral activity, particularly against myxoviruses.2,3 The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase.1,3 The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5-monophosphate.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Willis, R.C.,Carson, D.A., and Seegmiller, J.E. Adenosine kinase initiates the major route of ribavirin activation in a cultured human cell line. Proc. Natl. Acad. Sci. USA 75(7), 3042-3044 (1978). 2.Streeter, D.J.,Witkowski, J.T.,Khare, G.P., et al. Mechanism of action of 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole), a new broad-spectrum antiviral agent. Proc. Natl. Acad. Sci. USA 70(4), 1174-1178 (1973). 3.De Clercq, E. Specific targets for antiviral drugs. Biochemistry Journal 205, 1-13 (1982). 4.Balzarini, J.,Lee, C.-K.,Herdewijn, P., et al. Mechanism of the potentiating effect of ribavirin on the activity of 2’,3’-dideoxyinosine against human immunodeficiency virus. J. Biol. Chem. 266(32), 21509-21514 (1991). 5.Browne, M.J. Mechanism and specificity of action of ribavirin. Antimicrob. Agents Chemother. 15(6), 747-753 (1979). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 336.1 |
| 分子式 | C8H11N4O8P • 2Li |
| CAS号 | 66983-94-6 |
| 稳定性 | ≥ 2 years |
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