VX-661
货号：
21480-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 21480-5mg |
| 描述 | VX-661 is an investigational compound that promotes the maturation of delta F508 mutants of the cystic fibrosis transmembrane conductance regulator (CFTR).1 Delta F508 CFTR represents a class of CFTR mutation that is characterized by impaired processing of misfolded CFTR proteins and reduced accumulation of the protein at the cell surface.1 VX-661 is intended to facilitate trafficking of CFTR to the epithelial cell membrane. It may be combined with the CFTR potentiator ivacaftor (Item No. 15145) to stimulate both CFTR accumulation and opening at the apical epithelial surface.1,2 |
| 别名 | Tezacaftor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Petit, R.S., and Fellner, C. CFTR modulators for the treatment of cystic fibrosis. P.T. 39(7), 500-511 (2014).
2.Veit, G.,Avramescu, R.G.,Perdomo, D., et al. Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression. Sci. Transl. Med. 6(246), 246RA297 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 520.5 |
| 分子式 | C26H27F3N2O6 |
| CAS号 | 1152311-62-0 |
| 稳定性 | ≥ 2 years |
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