AN2728
货号：
21455-25mg 基本售价：
630.0 元 规格：
25 mg
产品信息
概述| 货号 | 21455-25mg |
| 描述 | AN2728 is a boron-based, topical anti-inflammatory agent that inhibits phosphodiesterase 4 (PDE4; IC50 = 0.11 µM).1 It is less potent against PDE1A, PDE3A, and PDE7A (IC50s = 6.12, 6.41, and 0.73 µM, respectively).1 AN2728 suppresses the release of the proinflammatory cytokines TNF-α, IL-2, INF-γ, IL-5, and IL-10 with IC50 values of 0.50, 0.59, 0.72, 2.25, and 2.58 µM, respectively.1 |
| 别名 | Crisaborole; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Freund, Y.R.,Akama, T.,Alley, M.R.K., et al. Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. FEBS Lett. 586, 3410-3414 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 251.1 |
| 分子式 | C14H10BNO3 |
| CAS号 | 906673-24-3 |
| 稳定性 | ≥ 2 years |
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