Hellebrin
货号：
21442-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 21442-1mg |
| 描述 | Hellebrin is a cardiac glycoside that potently inhibits the Na+/K+-ATPase by binding to it and blocking its non-canonical function as a receptor for cardiac glycosides.1,2 Hellebrin has a higher affinity for the α1β1 subunit of the Na+/K+-ATPase than the α2β1 or α3β1 complexes, in contrast to other cardiac glycosides.1 This affinity for the α1β1 complex correlates with its cancer cell growth inhibition (GI50 = 6-58 nM in various human cancer cell lines). Hellebrin also induces caspase-dependent apoptosis in Jurkat T cells.3 |
| 别名 | NSC 93134; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Moreno, Y.B.L.,Katz, A.,Miklos, W., et al. Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase. Mol. Cancer 12, 1-14 (2013).
2.Ogawa, H.,Shinoda, T.,Cornelius, F., et al. Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain. Proc. Natl. Acad. Sci. USA 106(33), 13742-13747 (2009).
3.Daniel, D.,Süsal, C.,Kopp, B., et al. Apoptosis-mediated selective killing of malignant cells by cardiac steroids: Maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives. Int. Immunopharmacol. 3, 1791-1801 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 724.8 |
| 分子式 | C36H52O15 |
| CAS号 | 13289-18-4 |
| 稳定性 | ≥ 2 years |
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