BRL 54443
货号：
21263-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 21263-5mg |
| 描述 | BRL 54443 is a potent agonist of the serotonin (5-HT) receptor subtypes 5-HT1E and 5-HT1F(Ki values are 1.1 and 0.7 nM, respectively).1 It displays more than 30-fold selectivity over other 5-HT and dopamine receptors. At higher concentrations, BRL 54443 induces 5-HT2A-mediated contraction of mouse thoracic aorta strips in vitro(pEC50 = 6.5).2 It significantly reduces formalin-induced pain in rat hind paw.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Klein, M.T.,Dukat, M.,Glennon, R.A., et al. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: A comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J. Pharmacol. Exp. Ther. 337(3), 860-867 (2011).
2.McKune, C.M. and Watts, S.W. Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J. Pharmacol. Exp. Ther. 297(1), 88-95 (2001).
3.Granados-Soto, V.,Argüelles, C.F.,Rocha-González, H.I., et al. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience 165(2), 561-568 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 230.3 |
| 分子式 | C14H18N2O |
| CAS号 | 57477-39-1 |
| 稳定性 | ≥ 2 years |
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