Granisetron (hydrochloride)
货号：
21239-100mg 基本售价：
630.0 元 规格：
100 mg
产品信息
概述| 货号 | 21239-100mg |
| 描述 | Granisetron is a serotonin 5-HT3 receptor antagonist (Ki = 3.9 nM) that exerts anti-emetic effects by preventing the binding of serotonin to 5-HT3 receptors on the vagal afferent nerves in the gut and brainstem.1 Antagonists of 5-HT3, including granisetron, have been shown to prevent nausea and emesis in patients undergoing chemotherapy in clinical trials.2 |
| 别名 | BRL 43694; |
性能| 供应商 | Cayman |
| 应用文献 |
1.López-Rodríguez, M.L.,Benhamú, B.,Morcillo, M.J., et al. Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT3 receptors. Journal of Medicinal Chemistry 42(24), 5020-5028 (1999).
2.Hesketh, P.J. Comparative review of 5-HT3 receptor antagonists in the treatment of acute chemotherapy-induced nausea and vomiting. Cancer Investigation 18(2), 163-173 (2000).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348.9 |
| 分子式 | C18H24N4O • HCl |
| CAS号 | 107007-99-8 |
| 稳定性 | ≥ 2 years |
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