POM 1
货号：
21160-5g 基本售价：
630.0 元 规格：
5 g
产品信息
概述| 货号 | 21160-5g |
| 描述 | POM 1 is a polyoxometalate that inhibits ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) 1 and 3 with Ki values of 2.58 and 3.26 µM, respectively.1 It demonstrates 10-fold lower inhibitory activity for NTPDase 2 (Ki = 28.8 µM) and does not inhibit P2Y12 receptors (Ki > 10 µM).1 Inhibition of ecto-NTPDases that are capable of hydrolyzing nucleoside tri- and diphosphates (i.e., ATP, ADP, UTP, or UDP) can result in a potentiation of purinergic signaling due to an increase in the extracellular nucleotide concentrations. This subtype-selective NTPase inhibitor has been used to investigate the mechanisms of purinergic signaling.2 |
| 别名 | Sodium Metatungstate;Sodium Polyoxotungstate; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Müller, C.E.,Iqbal, J.,Baqi, Y., et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg. Med. Chem. Lett. 16(23), 5943-5947 (2006).
2.Pinheiro, A.R.,Paramos-de-Carvalho, D.,Certal, M., et al. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun. Signal. 11, 70 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% |
| 计算分子量 | 2986.1 |
| 分子式 | Na6O39W12 • H2O |
| CAS号 | 314075-43-9 |
| 稳定性 | ≥ 2 years |
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