| 货号 | 21039-250mg |
| 描述 | 2-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine (Item Nos. 16376|13956) as a substrate.1,2 Through its interaction with other modified nucleosides, 2-O-methylguanosine is thought to stabilize the structure of the tRNA.3 2-O-Methylguanosine can also be found in rRNA.4,5 Normal and modified nucleosides, including 2-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Persson, B.C.,Jäger, G. and Gustafsson, C. The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2-O-methyltransferase activity. Nucleic Acids Res. 25(20), 4093-4097 (1997). 2.Yamagami, R.,Tomikawa, C.,Shigi, N., et al. Folate-/FAD-dependent tRNA methyltransferase from Thermus thermophilus regulates other modifications in tRNA at low temperatures. Genes Cells 21(7), 740-754 (2016). 3.Urbonavičius, J.,Duand, J.M.B. and Björk, G.R. Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulence genes in Shigella flexneri. J. Bacteriol. 184(19), 5348-5357 (2002). 4.Barciszewska, M.Z.,Mashkova, T.D. and Barciszewski, J. The primary structure of lupin seed 5.8 S ribosomal RNA. Biochim Biophys. Acta. 1049(3), 343-345 (1990). 5.Sirum-Connolly, K. and Mason, T.L. The role of nucleotide modifications in the yeast mitochondrial ribosome. Nucleic Acids Symp. Ser. 33, 73-75 (1995). 6.Mori, T.,Guo, M.W.,Li, X., et al. Isolation and identification of apoptosis inducing nucleosides from CD57+ HLA-DRbright natural suppressor cell line. Biochem. Biophys. Res. Commun. 251(2), 416-422 (1998). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 297.3 |
| 分子式 | C11H15N5O5 |
| CAS号 | 2140-71-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |