Fevipiprant
货号：
20263-500ug 基本售价：
630.0 元 规格：
500 ug
产品信息
概述| 货号 | 20263-500ug |
| 描述 | Fevipiprant is a prostaglandin D2(PGD2; Item No. 12010) receptor antagonist with a Kd value of 1.14 nM for CRTH2/DP2 and a relatively slow dissociation from this receptor (half-life = 14.4 minutes).1 It has been shown to inhibit PGD2-stimulated human eosinophil shape change in whole blood assays (IC50 = 0.44 nM) and to inhibit PGD2-induced cytokine release in human Th2 cells (IC50s = 2.56 and 1.4 nM for IL-5 and IL-13, respectively).1 This compound has undergone testing in a phase II clinical study in uncontrolled allergic asthma.2 |
| 别名 | NVP-QAW039;QAW039; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sykes, D.A.,Bradley, M.E.,Riddy, D.M., et al. Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Mol.Pharmacol. 89(5), 593-605 (2016).
2.Erpenbeck, V.J.,Popov, T.A.,Miller, D., et al. The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma. Pulm.Pharmacol.Ther. 39, 54-63 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 426.4 |
| 分子式 | C19H17F3N2O4S |
| CAS号 | 872365-14-5 |
| 稳定性 | ≥ 2 years |
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