MK-5108
货号：
19167-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 19167-1mg |
| 描述 | The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM).1 It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types.1,2 It is effective in vivo, inhibiting the growth of xenograft tumors in mice.1 |
| 别名 | VX-689; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Harrington, E.A.,Bebbington, D.,Moore, J., et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Medicine 10(3), 262-267 (2004).
2.Shimmoura, T.,Hasako, S.,Nakatsuru, Y., et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Molecular Cancer Therapeutics 9(1), 157-166 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 461.9 |
| 分子式 | C22H21ClFN3O3S |
| CAS号 | 1010085-13-8 |
| 稳定性 | ≥ 2 years |
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