CAY10700
货号：
18905-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 18905-1mg |
| 描述 | Prostaglandin E2(PGE2; Item No. 14010) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both COX-2 and microsomal PGE synthase-1 (mPGES-1). CAY10700 is an orally bioavailable inhibitor of mPGES-1 (IC50 = 0.24 µM in an in vitro human whole blood assay).1 It is inactive against COX-1 and COX-2 (9% inhibition at 100 µM and 16% at 30 µM, respectively).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schiffler, M.A.,Antonysamy, S.,Bhattachar, S.N., et al. Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors. Journal of Medicinal Chemistry 59(1), 194-205 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 334.8 |
| 分子式 | C16H19ClN4O2 |
| CAS号 | 1381846-21-4 |
| 稳定性 | ≥ 2 years |
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