Losartan Carboxaldehyde
货号：
18855-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 18855-1mg |
| 描述 | Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan (Item No. 10006594). It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions.1 At 1 µM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α (Item No. 16010).1 Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 µM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.2,3 |
| 别名 | DuP-167;EXP3179; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Krämer, C.,Sunkomat, J.,Witte, J., et al. Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: Role of the active metabolite EXP3179. Circulation Research 90(7), 770-776 (2002).
2.Schupp, M.,Lee, L.D.,Frost, N., et al. Regulation of peroxisome proliferator-activated receptor γ activity by losartan metabolites. Hypertension 47(3), 586-589 (2006).
3.Kappert, K.,Tsuprykov, O.,Kauffman, J., et al. Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARγ activation. Hypertension 54(4), 738-743 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 420.9 |
| 分子式 | C22H21ClN6O |
| CAS号 | 114798-36-6 |
| 稳定性 | ≥ 2 years |
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