Cuspin-1
货号：
18526-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 18526-5mg |
| 描述 | The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA).1 Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 µM.2 Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.2 |
| 别名 | Chemical Upregulator of SMN Protein-1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Burghes, A.H.M., and Beattie, C.E. Spinal muscular atrophy: Why do low levels of SMN make motor neurons sick? Nature Reviews.Neuroscience 10(8), 597-609 (2009).
2.Letso, R.R.,Bauer, A.J.,Lunn, M.R., et al. Small molecule screen reveals regulation of survival motor neuron protein abundance by Ras proteins. ACS Chemical Biology 8(5), 914-922 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 276.1 |
| 分子式 | C13H10BrNO |
| CAS号 | 337932-29-3 |
| 稳定性 | ≥ 2 years |
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