Pexidartinib
货号：
18271-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 18271-5mg |
| 描述 | Colony stimulating factor-1 (CSF1) is a cytokine that is involved in the recruitment and activation of tissue macrophages. It exerts these effects by binding to its corresponding receptor tyrosine kinase, the cFMS/CSF1 receptor (CSF1R). Pexidartinib is a brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3 (IC50s = 20, 10, and 160 nM in vitro, respectively).1 It has been used in combination with paclitaxel (Item No. 10461) to block macrophage recruitment in mammary tumor-bearing mice, thus slowing primary tumor development and metastasis.1 Pexidartinib has also been used to block microglial stimulation of glioblastoma invasion in both cell culture and a mouse model of glioblastoma multiforme.2 |
| 别名 | PLX3397; |
性能| 供应商 | Cayman |
| 应用文献 |
1.DeNardo, D.G.,Brennan, D.J.,Rexhepaj, E., et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1(1), 54-67 (2011).
2.Coniglio, S.H.,Eugenin, E.,Dobrenis, K., et al. Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Molecular Medicine 18, 519-527 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 417.8 |
| 分子式 | C20H15ClF3N5 |
| CAS号 | 1029044-16-3 |
| 稳定性 | ≥ 2 years |
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