(±)-Nicotine-d3
货号：
18256-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 18256-5mg |
| 描述 | (±)-Nicotine-d3 is intended for use as an internal standard for the quantification of (±)-nicotine (Item No. 16535) by GC- or LC-mass spectrometry. (±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs; Kis = 481 and 11.1 nM for α3β4 and α4β2 subtypes, respectively) and possesses addictive and teratogenic properties.1 (−)-(S)-Nicotine is significantly more active at binding nAChRs compared to the (+)-(R) antipode, thus nicotine is typically synthesized as (−)-(S)-nicotine with only 0.2-1% of the (+)-(R) isomer present.2 |
| 别名 | DL-Nicotine-d3;(±)-Nicotine-methyl-d3; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zaveri, N.,Jiang, F.,Olsen, C., et al. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. Journal of Medicinal Chemistry 53, 8187-8191 (2010).
2.Clayton, P.,Lu, A., and Bishop, L. The pyrolysis of (−)-(S)-nicotine: Racemization and decomposition. Chirality 22(4), 442-446 (2010).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d3) |
| 计算分子量 | 165.3 |
| 分子式 | C10H11D3N2 |
| CAS号 | 69980-24-1 |
| 稳定性 | ≥ 1 year |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
