| 货号 | 18049-1mg |
| 描述 | Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol is a folate analog antimetabolite with antineoplastic activity.1,2 At nanomolar conentrations, it inhibits GART preventing de novo purine synthesis, inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.3 |
| 别名 | DDATHF;(6R)-Dideazatetrahydrofolate;LY 264618; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Beardsley, G.P.,Moroson, B.A.,Taylor, E.C., et al. A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis. The Journal of Biological Chemisty 264(1), 328-333 (1989). 2.Pizzorno, G.,Moroson, B.A.,Cashmore, A.R., et al. (6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid effects on nucleotide metabolism in CCRF-CEM human T-lymphoblast leukemia cells. Cancer Research 51, 2291-2295 (1991). 3.Bronder, J.L., and Moran, R.G. Antifolates targeting purine synthesis allow entry of tumor cells into S phase regardless of p53 function. Cancer Research 62, 5236-5241 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 443.5 |
| 分子式 | C21H25N5O6 |
| CAS号 | 106400-81-1 |
| 稳定性 | ≥ 2 years |
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