DY 131
货号：
17999-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 17999-5mg |
| 描述 | The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the ER family and are expressed in tissues with high metabolic demand. DY 131 is a selective agonist of the ERRβ/γ receptor (EC50 = 130 nM).1,2 It does not affect the ERRα receptor nor the ERs α and β at concentrations up to 30 µM.1,2 DY 131 has been used to potentiate ERRγ-induced growth inhibition in LNCaP and DU145 prostate cancer cell lines in order to demonstrate an antiproliferative/tumor-suppressing function for ERRγ in prostate cancer.3 |
| 别名 | GSK9089; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zuercher, W.J.,Gaillard, S.,Orband-Miller, L.A., et al. Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ. Journal of Medicinal Chemistry 49(9), 3107-3109 (2005).
2.Yu, D.D., and Forman, B.M. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorganic & Medicinal Chemistry Letters 15(5), 1311-1313 (2005).
3.Yu, S.,Wang, X.,Ng, C.F., et al. ERRγ suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Research 67(10), 4904-4914 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 311.4 |
| 分子式 | C18H21N3O2 |
| CAS号 | 95167-41-2 |
| 稳定性 | ≥ 2 years |
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