BHPI
货号：
17750-500ug 基本售价：
630.0 元 规格：
500 ug
产品信息
概述| 货号 | 17750-500ug |
| 描述 | BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial, and ovarian cancer cell lines at concentrations ranging from 10 to 1,000 nM.1 It is effective in vivo, driving tumor regression in mice bearing MCF-7 xenografts at a dose of 15 mg/kg daily.1 BHPI specifically inhibits ERα-dependent gene expression and protein synthesis by activating the unfolded protein response in cells.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Andruska, N.D.,Zheng, X.,Yang, X., et al. Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proceedings of the National Academy of Sciences of the United States of America 112(15), 4737-4742 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 331.4 |
| 分子式 | C21H17NO3 |
| CAS号 | 56632-39-4 |
| 稳定性 | ≥ 2 years |
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