ML-299
货号：
17632-500ug 基本售价：
630.0 元 规格：
500 ug
产品信息
概述| 货号 | 17632-500ug |
| 描述 | ML-299 is a dual inhibitor of the two mammalian forms of phospholipase D (PLD), PLD1 and PLD2(IC50s = 6 and 20 nM, respectively).1 It dose-dependently decreases the invasive migration of U98-MG glioblastoma cells into matrigel.1 ML-299 penetrates the central nervous system and is functional in vivo when given intraperitoneally.2 As PLD1 and PLD2 have roles in cancer and viral infection, ML-299 has potential applications in oncology and virology.2 |
| 别名 | CID 56593087; |
性能| 供应商 | Cayman |
| 应用文献 |
1.OReilly, M.C.,Scott, S.A.,Brown, K.A., et al. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: Discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. Journal of Medicinal Chemistry 56(6), 2695-2699 (2013).
2.Scott, S.A.,OReilly, M.C.,Daniels, J.S., et al. Development of a selective, allosteric PLD1/2 inhibitor in a novel scaffold. P01 ES013125, 1-4 (2013).
|
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 489.4 |
| 分子式 | C23H26BrFN4O2 |
| CAS号 | 1426916-00-8 |
| 稳定性 | ≥ 2 years |
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