ML-211
货号：
17630-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 17630-1mg |
| 描述 | Lysophospholipase 1 (LYPLA1) is a protein palmitoyl thioesterase responsible for depalmitoylation of the oncogene HRas.1,2 Palmitoylation of such oncogenes is thought to be required for trafficking and malignant transformation, making LYPLA1 a target for downregulating oncogenic signaling.1,2 ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM).3 It can also inhibit the serine hydrolase ABHD11 with an IC50 value of 10 nM but is ≥ 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Martin, B.R., and Cravatt, B.F. Large-scale profiling of protein palmitoylation in mammalian cells. Nature Methods 6(2), 135-138 (2009).
2.Dekker, F.J.,Rocks, O.,Vartak, N., et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nature Chemical Biology 6, 449-456 (2010).
3.Adibekian, A.,Martin, B.R.,Speers, A.E., et al. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2). 1 R01 CA132630, 1-42 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 418.5 |
| 分子式 | C25H30N4O2 |
| 稳定性 | ≥ 2 years |
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