| 货号 | 17246-500ug |
| 描述 | Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.1 MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation.2 MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity.3 This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM.4 |
| 别名 | Matrix Metalloproteinase-3 Inhibitor VIII;Stromelysin-1 Inhibitor VIII; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Nagase, H., and Woessner, J.F., Jr. Matrix metalloproteinases. The Journal of Biological Chemisty 274(31), 21491-21494 (1999). 2.Sindermann, J.R.,Köbbert, C.,Voss, R., et al. Transgenic model of smooth muscle cell cycle reentry: Expression pattern of the collageneous matrix. Cardiovascular Pathology 17(2), 72-80 (2008). 3.Macpherson, L.J.,Bayburt, E.K.,Capparelli, M.P., et al. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. Journal of Medicinal Chemistry 40(16), 2525-2532 (1997). 4.Jeng, A.Y.,Chou, M., and Parker, D.T. Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase. Bioorganic & Medicinal Chemistry Letters 8(8), 897-902 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 406.5 |
| 分子式 | C20H26N2O5S |
| CAS号 | 208663-26-7 |
| 稳定性 | ≥ 2 years |
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