| 货号 | 17188-500ug |
| 描述 | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is an aggrecanase in that it cleaves aggrecan, a major proteoglycan in cartilage. While it has key roles in cartilage destruction associated with osteoarthritis, ADAMTS-5 is also involved in other pathways, including neurological processes.1,2 ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1).3,4 |
| 别名 | A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 Inhibitor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bondeson, J.,Wainwright, S.,Hughes, C., et al. The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: A review. Clin.Exp.Rheumatol. 26(1), 139-145 (2008). 2.Lemarchant, S.,Pruvost, M.,Montaner, J., et al. ADAMTS proteoglycanases in the physiological and pathological central nervous system. Journal of Neuroinflammation 10, 1-8 (2013). 3.Bursavich, M.G.,Gilbert, A.M.,Lombardi, S., et al. Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters 17, 1185-1188 (2007). 4.Gilbert, A.M.,Bursavich, M.G.,Lombardi, S., et al. 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorganic & Medicinal Chemistry Letters 17, 1189-1192 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 449.9 |
| 分子式 | C16H11ClF3N3OS3 |
| CAS号 | 929634-33-3 |
| 稳定性 | ≥ 2 years |
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