S-(4-Nitrobenzyl)-6-thioinosine
货号：
16403-25mg 基本售价：
630.0 元 规格：
25 mg
产品信息
概述| 货号 | 16403-25mg |
| 描述 | S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog that competitively inhibits the equilibrative nucleoside transporter 1 (Kd = 0.1-1.0 nM; IC50s = 4.6 and 3.6 nM in rat and human, respectively).1,2 It blocks adenosine flux across the plasma membrane, thereby potentiating the interaction of extracellular adenosine with purinoreceptors, which can affect cardiac signaling associated with adenosine.2 |
| 别名 | NBMPR;NBTI;NSC 296962; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Aronow, B.,Allen, K.,Patrick, J., et al. Altered nucleoside transporters in mammalian cells selected for resistance to the physiological effects of inhibitors of nucleoside transport. The Journal of Biological Chemisty 260(10), 6226-6233 (1985).
2.Yao, S.Y.M.,Ng, A.M.L.,Muzyka, W.R., et al. Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues. The Journal of Biological Chemisty 272(45), 28423-28430 (1997).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 419.4 |
| 分子式 | C17H17N5O6S |
| CAS号 | 38048-32-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
